A discussion on Wellness Panel (Not for diagnostic purposes)

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• Definition: A wellness panel is a set of blood tests designed to provide a general overview of an individual's health status and identify potential risk factors for various diseases. While traditional wellness panels often use immunoassays, LC-MS is increasingly being used for its multiplexing capabilities and accuracy.

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• What they do: Wellness panels help individuals and healthcare providers assess overall health, detect early signs of disease, monitor the effectiveness of treatments, and make informed decisions about lifestyle changes. LC-MS enhances these panels by allowing for the simultaneous measurement of a wider range of biomarkers with improved accuracy and precision.

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• What they solve: Wellness panels can aid in the early detection of conditions like heart disease, diabetes, liver and kidney problems, and other health issues. LC-MS's ability to measure multiple analytes in a single run makes it more efficient and cost-effective for comprehensive wellness screening.

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Example molecular systems and their uses (LC-MS applications):

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• Lipidomics profiling: LC-MS/MS allows for detailed analysis of lipids (e.g., phospholipids, sphingolipids), providing a more comprehensive assessment of cardiovascular risk than traditional cholesterol measurements.

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• Amino acid profiling: LC-MS can quantify amino acids, which can be useful for assessing metabolic disorders, nutritional status, and other health conditions.

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• Vitamin D metabolites: LC-MS/MS is the preferred method for measuring different forms of vitamin D, providing a more accurate assessment of vitamin D status.

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• Oxidative stress markers: LC-MS can be used to quantify markers of oxidative stress, which are implicated in various diseases.

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• Drug monitoring: LC-MS can be incorporated into wellness panels to monitor levels of therapeutic drugs, ensuring optimal dosing and adherence.